Title: Expression of MMP-9 and TIMP-1 in oral squamous cell carcinoma
Abstract: Objective To study the expression and the relationship of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in oral squamous cell carcinoma (OSCC) so as to investigate their role in the development of OSCC .Methods 20 cases of normal oral mucosa (NM) and 40 cases of OSCC were used to detect the expression of MMP-9 and TIMP-1 by immunohistochemistry S-P method .Results The expression rates of well differentiated squamous cell carcinoma(WDSCC) and poorly differentiated squamous cell carcinoma(PDSCC) were both higher than those of normal oral mucosa(NM).The TIMP-1 expression rates of WDSCC and PDSCC were all higher than NM.Conclusions MMP-9 may play an important role in the development of OSCC.MMP-9 was controlled negatively by TIMP-1.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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