Title: The expressions of vascular endothelial growth factor C and receptor-3 mRNA in laryngeal squamous cell carcinoma
Abstract: Objective To explore the expressions of vascular endothelial growth factor C(VGEF-C) and receptor-3 mRNA in laryngeal squamous cell carcinoma(LSCC) correlated to lymph node invasion of the neck,and add to understanding of mechanisms underlying growth and metastasis of laryngeal carcinoma.Methods VEGF-C and VEGFR-3 mRNA in 24 LSCC samples and 5 samples collected from tumor-adjacent normal mucosa were detected by in-situ hybridization techniques.Data obtained were classified based on age,TMN staging,pathological grading and lymphatic metastasis.Correlations of age,TNM staging and pathological grading with varied pathological findings and presence of lymphatic metastasis were analyzed,respectively.Results In-situ hybridization showed higher levels of VEGF-C and VEGFR-3 mRNA in LSCC vs tumor-adjacent normal tissue.Expressions of VEGF-C and VEGFR-3 mRNA were not found to be correlated with age,TNM staging and pathological grading.In addition,higher levels of VEGF-C and VEGFR-3 mRNA were detected in patients with vs without tumor metastasis.Conclusion Enhanced expressions of VEGF-C and VEGFR-3 mRNA were shown in LSCC and may be one of factors underlying oncogenesis.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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