Title: Comparison of the clinical effect of Magnesium Isoglycyrrhizinate and Compound Ammonium Glycyrrhetate on drug-induced liver injury after blood cancer chemotherapy
Abstract: Objective To compare the clinical effect and adverse reactions of Magnesium Isoglycyrrhizinate(MI) and Compound Ammonium Glycyrrhetate(CAG) on drug-induced liver injury(DILI) after blood cancer chemotherapy.Methods Forty-eight cases of DILI after blood cancer chemotherapy were divided into two groups.The patients in MI group(n=24) were given MI injection 150 mg,while CAG group(n=24) was given CAG injection 60mL.Both groups were added 250 mL 5% glucose injection,once every day,and continually vein injected for 2 weeks.Results After two weeks,the symptoms and liver function parameters of two groups were significantly improved,and the rates of improvement had no significant differences(P0.05),but the improving dates had significant differences(P0.05).The effectual rate of MI group was significantly higher than that of CAG group(P0.05).No obvious adverse reactions were found in MI group,while four cases of facial edema,one case of high blood pressure were found in CAG group.Conclusion The clinical effect of MI on DILI after blood cancer chemotherapy is better than that of CAG.The rate of adverse reactions of MI is significantly lower than that of CAG.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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