Title: Comparison of heart failure rat models between renal artery stenosis and coronary ligation caused
Abstract: Objective To compare the effect of two heart failure rat models established by renal artery stenosis and coronary ligation,respectively.Methods Heart failure rat models were established by ligation of two sides′ renal artery(renal artery stenosis group) and descending anterior branch of coronary(coronary ligation group),respectively.Blood pressure,heart rate,left ventricular end diastolic diameter(LVDD),left ventricular end systolic diameter(LVSD) and left ventricular ejection fraction(EF) were tested 2 weeks,1 month,3 months,6 months,8 months after operation.Results The 24 hours mortality rate in renal artery stenosis group and coronary ligation group were 22.2% and 44.4%,respectively,(P0.01);the successful rate of heart failure model were 56% and 43%,respectively,(P0.01);the time of model success were 6 months and 2 weeks,respectively,(P0.01);occurrence of hypertension were 65% and 1.8%,respectively,(P0.01);mean heart rate were 430bpm and 670bpm,respectively,(P0.01);no significantly difference were found among the LVDD,LVSD and EF in two groups.Conclusion Both ligation of two sides′ renal artery and descending anterior branch of coronary can establish heart failure rat models,the renal artery stenosis rat models can be used in hypertension caused heart failure experiment,coronary ligation rat models can be used in coronary heart disease caused heart failure experiment.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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