Title: Expression and biological significance of CyclinD1,p15 in esophageal squamous carcinoma
Abstract: Objective:To investigate CyclinD1 and p15 expression in the esophageal squamous carcinoma and the putative roles in carcinogenesis of esophageal squamous carcinoma. Methods: The expressions of CyclinD1 protein,p15 protein and p15 mRNA were examined by streptavidin-horseradish peroxidase(SP)immunohistochemistry (IHC) method and in suit hybridyzation (ISH) in 48 cases of esophageal squamous carcinoma, 18 cases of esophageal dysplasia and 10 cases of incisal margin normal tissues. Results: The positive expression rates of CyclinD1 in esophageal carcinoma (58.3 %) and dysplasia tissues(66.7 %) were both higher than that in normal tissues (0 ); The positive expression rates of p15 mRNA and p15 protein in esophageal carcinoma were 56.3 % and 47.9 %, which were respectively lower than those in incisal margin normal tissues and adjacent dysplasia tissues (P0.05). There was marked correlation between the expression of p15 mRNA and p15 protein in esophageal carcinoma tissues (P0.05). There have negative relation between the expression of CyclinD1 and p15 protein in esophageal carcinoma tissues (P0.05). Conclusion: The high expressions of CyclinD1 ,which may be the earlier molecular event during the esophageal carcinogenesis and the low expressions of p15 might involve in esophageal carcinogenesis, CyclinD1 and p15 protein had positive or negative effect on the carcinoma progression respectively, and there may be some interaction between them.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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