Title: The Effect of Taohong Siwu Granule on Acute Myocardial Ischemia injury Induced by Pituitrin in Rats
Abstract: Objective:To observe the effect of Taohong Siwu granule(THSWG)on with acute myocardial ischemia injury induced by pituitrin(Pit) in rats.Method: The 70 rats were divided into normal control group,model control group,amiodarone 0.094 5 g·kg-1 group,CSDP 2.7 pills·kg-1 group,THSWG 18.36,9.18,4.59 g·kg-1 group.The rat acute myocardial ischemia injury was induced by femoral vein perfusion with Pit,and the percentage changes of the T wave and the heart rate were observed after 30,60,90 min of administration.And other rat acute myocardium ischemia models were established by sublingual venous injection of Pit,the levels of the serum creatine phosphokinase(CK) and the lactate dehydrogenase(LDH) of the rats were examined after taking THSWG for 5 days.Result: Compared with the model control group,the percentage changes of the T wave and the heart rate were significantly reduced(P0.01),the levels of the serum CK and LDH of the rat models were also significantly decreased(P0.01) after taking THSWG.Conclusion:THSWG could protect the rats against acute myocardial ischemia induced by Pit.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot