Title: Protective effects and mechanism of Guanxinkang capsules on myocardial injury induced by isoproterenol in rats
Abstract: Aim To study the effects and mechanism of Guanxinkang capsules on myocardial injury induced by isoproterenol in rats.Methods 30 male Wistar rats were randomly divided into 3 groups:control group,acute myocardial ischemia group and Guanxinkang capsules group.Rats were given injections of ISO subcutaneously.Electrocardiography were performed,serum and myocardium creatine kinase(CK),creatine kinase MBmass(CK-MB),lactate dehydrogenase(LDH) and nitric oxide(NO) were detected,and the levels of NO and endothelins(ET) in myocardium were measured as well.Results The rising degree of ST-T obviously decreased in Guanxinkang capsules group,and the levels of serum CK,CK-MB and LDH decreased in Guanxinkang capsules group,compared with those of acute myocardial ischemia group(P0.01);In Guanxinkang capsules group,the NO levels in serum and myocardium increased significantly(P0.05),while the ET level in myocardium markedly decreased,compared with that of acute myocardial ischemia group(P0.05).Conclusion Guanxinkang capsules could effectively ameliorate the myocardium injury induced by acute myocardial ischemia.Changes of NO and ET levels might play an important role in the pathogenesis and progress of myocardium injury.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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