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{'14C-HSR-803を用いてラットおよびイヌにおける吸収,分布および排泄について検討した.1.14C-RSR-803をラット,イヌに経口投与した時,血液および血清中放射能濃度は投与後0.5~1時間でCmaxに達し,以降血液ではTl/2はそれぞれ3.42,10.30時間,血清では3.78,10.12時間で減衰した.また,ラットにおける吸収部位は腸全域であり,特に十二指腸で速やかであった.2.14C-HSR-803をラットに経口投与した時,小腸,胃の上部消化管および腎臓,肝臓に高い放射能濃度が認められたが,中枢神経系への移行は少なかった.また,各組織からの消失は速やかであった.静脈内投与において,胃壁に高い放射能の移行が確認された.3.14C-HSR-803をラット,イヌに経口投与した時,投与後168時間までに投与量のそれぞれ63.6,46.7%が尿中へ,35.7,50.9%が糞中へ排泄された.また,ラットとイヌの胆汁中排泄率は,投与後24時間までにそれぞれ68.1,79.3%であった.また,ラットにおいて腸肝循環の存在が確認された.4.血清蛋白結合率は,0.2~10μg/mlの濃度範囲において,ヒト,ラットおよび・イヌでそれぞれ95.5,79.6および57.5%であった.': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2333770361', 'counts_by_year': [], 'updated_date': '2024-09-19T10:05:50.506630', 'created_date': '2016-06-24'}