Title: Expression of STAT3 and Survivin in Gastric Cancer and Its Significance
Abstract: [Purpose] To investigate the expression of STAT3 and survivin in gastric cancer and its correlation with the clinicopathological features. [Methods] SABC immunohistological staining was used to detect the expression of STAT3 and survivin in 40 cases of gastric cancer tissue and tissue. [Results] The expression rate of STAT3 and survivin in 40 cases with gastric cancer tissue were 70% and 75% respectively, which were much higher than that cancer around tissue(χ2=30.000、χ2=37.968,P0.001).The expression level of STAT3 was related to the invasive depth,lymph node metastasis and TNM stage(χ2=6.114、χ2=4.358、χ2=10.957,P0.05). There was no relationship between the expression of survivin and the clinicopathological feature in gastric cancer (P0.05). The expression of survivin had a positive correlation with that of STAT3 (χ2=12.857,P=0.000,r=0.533). [Conclusion] Overexpression of STAT3 and survivin play an important role in the pathogenesis of gastric cancer, and they appear to be two valuable markers for early diagnosis and treatment of gastric carcinoma. Survivin might be functioning on anti-apoptosis through the regulation of STAT3 protein.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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