Title: Association of acute-phase proteins,interleukin-6,tumor necrosis factor-α with diabetic nephropathy in type 2 diabetes mellitus
Abstract: Objective To study the levels of serum acute-phase proteins,interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in different stages of diabetic nephropathy in type 2 diabetes mellitus(T2DM) and to explore the clinical significance.Methods One hundred and five patients with T2DM diagnosed by WHO(1999) criteria were divided into three subgroups according to their urinary albumin excretion rate(UAER): 34 cases normal UAER group(NA group),31 cases microalbuminuria group(MA group) and 30 cases clinical proteinuria group(CA group).Thirty-three healthy individuals were selected as controls(NC group).The levels of acute-phase proteins including C reactive protein(CRP),α_1-acid glycoprotein(α_1-AAG),ceruloplasmin(CER) and haptoglobin(THP) were measured with immunoscattering assay,The levels of IL-6 and TNF-α were detected with electrochemiluminescence immunoassay.Results The levels of serum acute-phase proteins,IL-6,TNF-α were significantly higher in patients with T2DM than those in NC group(all P0.05).The levels of serum acute-phase proteins,IL-6 and TNF-α gradually increased with the increment of UAER(all P0.05).The levels of serum acute-phase proteins were positively correlated with those of IL-6 and TNF-α in both MA group and CA group(all P0.05).Conclusion There is an acute-phase reaction in diabetic nephropathy in patients with T2DM.The degree of acute-phase reaction is correlated with the degree of diabetic nephropathy,and the intensity of acute-phase reaction is positively correlated with the levels of IL-6 and TNF-α.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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