Title: Correlations between Skp2 and p27~(kip1) protein expressions and clinicopathological features of prostate cancer
Abstract:Objective:To investigate the correlation between Skp2 and p27kip1 protein expression and the clinicopathological features of prostatic carcinoma,and study the relationships between them.Methods:Skp2 a...Objective:To investigate the correlation between Skp2 and p27kip1 protein expression and the clinicopathological features of prostatic carcinoma,and study the relationships between them.Methods:Skp2 and p27kip1 protein expression were evaluated in the tissues of 41 human prostatic carcinomas as well as 20 benign prostatic hyperplasia(BPH)using immunohistochemistry.Results:The Skp2 labeling frequency in prostatic carcinoma was significantly higher than that in BPH(P0.01).The p27kip1 labeling frequency in prostatic carcinoma was significantly lower than that in BPH (P0.01). The Skp2 protein expression in prostatic carcinoma was positively correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage and histological grade(P0.05).The p27kip1 protein expression in prostatic carcinoma were inversely correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage and histological grade(P0.05).Conclusion:Expression of Skp2 protein may lead to decrease in level of p27kip1 in human prostatic carcinoma,indicating its involvement in the development of human prostatic carcinoma.In addition,Skp2 may be a new target for the treatment of prostate cancer.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Title: $Correlations between Skp2 and p27~(kip1) protein expressions and clinicopathological features of prostate cancer
Abstract: Objective:To investigate the correlation between Skp2 and p27kip1 protein expression and the clinicopathological features of prostatic carcinoma,and study the relationships between them.Methods:Skp2 and p27kip1 protein expression were evaluated in the tissues of 41 human prostatic carcinomas as well as 20 benign prostatic hyperplasia(BPH)using immunohistochemistry.Results:The Skp2 labeling frequency in prostatic carcinoma was significantly higher than that in BPH(P0.01).The p27kip1 labeling frequency in prostatic carcinoma was significantly lower than that in BPH (P0.01). The Skp2 protein expression in prostatic carcinoma was positively correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage and histological grade(P0.05).The p27kip1 protein expression in prostatic carcinoma were inversely correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage and histological grade(P0.05).Conclusion:Expression of Skp2 protein may lead to decrease in level of p27kip1 in human prostatic carcinoma,indicating its involvement in the development of human prostatic carcinoma.In addition,Skp2 may be a new target for the treatment of prostate cancer.