Title: Correlations between Skp2,p27~(kipl),PTEN protein expression and the clinicopathological features of prostate cancer
Abstract:Objective To investigate the correlation between Skp2,p27kipl,PTEN protein expression and the clinicopathological features of prostatic carcinoma,and the relationships between expression of Skp2,p27ki...Objective To investigate the correlation between Skp2,p27kipl,PTEN protein expression and the clinicopathological features of prostatic carcinoma,and the relationships between expression of Skp2,p27kipl and PTEN in prostate cancer.Methods Skp2,p27kipl and PTEN protein expression in the tissues of 41 human prostatic carcinomas as well as 20 benign prostatic hyperplasia(BPH)were studied using immunohistochemistry.Results The Skp2 labeling frequency in prostatic carcinoma were significantly higher than that in BPH(P0.001).The p27kipl labeling frequency in prostatic carcinoma was significantly lower than that in BPH(P0.001).The PTEN labeling frequency in prostatic carcinoma was also significantly lower than that in BPH(P0.001).The Skp2 protein expression in prostatic carcinoma was positively correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage,and histological grade(P0.05).The p27kipl and PTEN protein expression in prostatic carcinoma were inversely correlated with preoperative serum prostate-specific antigen level,extraprostatic extension,clinical stage,and histological grade(P0.05).Conclusions Expression of Skp2 protein may lead to decrease in level of p27 in human prostatic carcinoma,indicating its involvement in the development of human prostatic carcinoma.In addition,Skp2 may be a new target for the treatment of prostate cancer.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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