Title: Comparison of three methods used for implantation of renal VX2 carcinoma
Abstract: Objective To compare three methods of establishing renal VX2 carcinoma model. Methods Thirty-six healthy rabbits were used in this study, and VX2 carcinoma was successfully transplanted in 26 kidneys. Successful transplantation was done by three methods: (1) VX2 carcinoma was cut into tiny pieces in saline to make suspension of tumor tissues and the suspension was then injected into renal cortex guided by ultrasound. (2) Rabbits were operated and VX2 carcinoma was implanted into the kidney. (3) Kidneys were exposed under surgery and the suspension was injected into renal cortex. Results Animal models of renal VX2 carcinoma were successfully established using the three methods. The rates of success of the three methods were (10/28)35.71%,(4/12)33.33% and (12/14)85.71%, respectively. Conclusion All the three methods are feasible in VX2 tumor implantation. However the third method, in which the VX2 suspension is injected into renal cortex under surgical exposure, has a higher successful rate.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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