Title: Urinary transforming growth factor‐<b>β</b>1 is an indicator of histological chronicity in IgA nephropathy
Abstract: SUMMARY: This study examined urinary excretion of transforming growth factor‐β1 (TGF‐β1) in adult IgA nephropathy and compared this with clinical and histological parameters. TGF‐β1 was measured by enzyme‐linked immunosorbent assay in 24‐h urine specimens from 25 patients with IgA nephropathy (17 men, eight women). Urine from eight age‐matched control subjects served as the control. Serum TGF‐β1 was also measured in 16 out of the 25 patients and six age‐matched control subjects. TGF‐β1 was detected in the urine in 72% of IgA nephropathy patients(18/25), but was not detected in any of the control subjects. Patients with decreased renal function (creatinine clearance (Ccr) < 80 mL/min) had higher urine levels of TGF‐β1 than those with normal renal function (Ccr ≥ 80 mL/min) (141.8 ± 60.0 ng/day vs 39.7 ± 33.2 ng/day, P < 0.01). The level of TGF‐β1 gave a negative correlation with Ccr ( r = −0.62, P = 0.001), but not with proteinuria ( r = 0.11, P = 0.58). Twenty‐two of the patients were evaluated histologically. The urinary TGF‐β1 levels correlated with both global sclerosis and interstitial volume ( r = 0.52, P < 0.05, and r = 0.51, P < 0.05, respectively). However, there was no correlation between TGF‐β1 levels and glomerular intracapillary inflammatory cell score, mesangial proliferation score or the matrix score. No correlation was found between TGF‐β1 levels and the number of glomerular or interstitial CD68 + cells. No significant differences in serum TGF‐β1 levels were observed between patients with normal Ccr and those with decreased Ccr. Also, its levels were found to be independent of the urine levels. In conclusion, 24‐h urinary TGF‐β1 excretion was found to correlate with Ccr, global sclerosis and interstitial volume, demonstrating that urinary TGF‐β1 is an indicator of chronicity in adult IgA nephropathy.
Publication Year: 2000
Publication Date: 2000-12-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 2
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