Title: Expression and prognosis prediction of MCP-1 in children with acute glomerulonephritis
Abstract: Objectives To investigate the expression of monocyte chemoattractant protein-1(MCP-1)in serum and urine of children with acute glomerulonephritis(AGN),and to evaluate it as a predictor of clinical outcome. Methods Total of children with AGN and 30 health children were enrolled. MCP-1 in serum and urine were measured by Enzyme-linked immunosorbent assay(ELISA);Urinary creatinine,serum creatinine,urinary protein,24 h urinary protein excretion,and complement component 3(C3)were measured by routine laboratory methods. Serum superoxide dismutase(SOD)and lipid peroxides(LPO)were measured by biochemistry methods. At the same time,the relationships of MCP-1 with renal function,proteinuria,index of oxidative damage(SOD and LPO)and creatinine clearance(Ccr)were analyzed. Results In the acute phase of AGN,the serum and urinary MCP-1 were significantly higher than in the resolution phase and controls(P 0.05=while those levels in the resolution phase were significantly higher than in controls(P 0.05=. Urinary MCP-1 was positively correlated with proteinuria and LPO(r = 0.58 - 0.83,P 0.05=and negatively correlated with Ccr and SOD(r = 0.32 ~ 0.83,P 0.05=. However,there are no significant correlation between urinary and serum MCP-1(r = 0.21,P 0.05)and no significant correlation of serum MCP-1 with proteinuria,Ccr,SOD and LPO(r = 0.15 ~ 0.28,P 0.05). Conclusions Serum and urinary MCP-1 were abruptly elevated in children with AGN,which may play a role in immune-mediated glomerular injury. Urinary MCP-1 might be a reliable predictor to evaluate the degree of inflammation and renal damage in children with AGN.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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