Title: Experimental study of transarterial infusion with 5-FU sustained-release microspheres for rabbit hepatic VX2 tumors
Abstract: Objective To study the therapeutic efficacy of 5-FU sustained-release microspheres infused through gastroduodenal artery for rabbits with VX2 liver carcinoma. Methods Forty rabbits implanted with liver VX2 tumors were randomly divided into 4 groups,with 10 rabbits in each group. All rabbits were demonstrated with liver neoplasmas by MSCT. During the open laparotomy,common hepatic artery was ligated under microsurgery temporarily,then a catheter was inserted via gastroduodenal artery under microscopy and follow by administration of therapeutic agents through the catheter. Group A (Control group 1) was given 0.5 to 1.0 ml saline; Group B (contrast agent group) was administrated with 0.5 to 1.0 ml ioversol injection; Group C (lipiodol group) received 0.5 to 1.0 ml lipiodol; Group D (5-FU sustained-release microsphere group) was infused with mixture of 10 mg 5-FU sustained-release microsphere and 1ml Ioversol. Mutislice spiral CT scan was performed to measure tumor volume on the 7th day after treatment. The tumor growth rates,necrosis rates were observed and cell apoptotic index was recorded by TUNEL. All parameter thus gained were compared among the A,B and D groups. Results One week after treatment,the 5-FU sustained-release microsphere group showed the growth of tumor was significantly inhibited,tumor growth rate lower than those of group A and group B (P 0.05),and showed no significant statistical difference to group C(P 0.05). The tumor necrosis rates had some differences in each group,with necrosis rates of group D and C much higher than those of group A and B (P 0.05). The tumor apoptotic indexes (AI) were 1.69 ± 0.18 (group A),1.75 ± 0.27 (group B),8.03 ± 0.63 (group D),respectively (P 0.05); there was significant statistical difference between groups D and group A. Conclusion The 5-FU sustained-release microspheres transarterial infusion to liver can inhibit the growth of hepatic tumor,induce the tumor cell apoptosis,aggravate the tumor necrosis,and thus is an effective chemoembolization agent.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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