Title: The therapeutic effect of interventional heated-Lipiodol perfusion combined with heated-Lipiodol injection into tumor for the treatment of VX2 liver cancer in experimental rabbits
Abstract: Objective To explore the therapeutic effect and clinical safety of interventional heated Lipiodol perfusion combined with heated-Lipiodol injection into tumor for the treatment of VX2 liver cancer in experimental rabbits. Methods VX2 liver cancer cells were inoculated into the livers of 30 New Zealand white rabbits to prepare the models of liver VX2. The animals were randomly and equally divided into study group(n = 15) and control group(n = 15). Interventional hepatic arterial infusion of heated-Lipiodol perfusion(60℃,2 ml) was performed in the rabbits of the study group,which was followed by heated-Lipiodol(60℃,1 ml) injection into the tumor three days later. For the rabbits of the control group,only transhepatic arterial infusion of 3 ml room-temperature(25℃) Lipiodol was employed. Before and after the procedure,the tumor sizes were measured by color Doppler ultrasonography and the serum ALT levels were determined. The results were analyzed and compared between the two groups. Results The tumor volume of the study group decreased from preoperative(1 565 ± 315)mm3to postoperative(1 054 ± 463)mm3,while the tumor volume of the control group decreased from preoperative(1 568 ± 323)mm3to postoperative(1 275 ± 472)mm3,the difference between the two groups was statistical significant(P 0.05). The serum ALT level was increased from preoperative(736 ± 212)u/L to postoperative(816 ± 247)u/L in the study group,while in control group it was increased from preoperative(745 ± 215)u/L to postoperative(796 ± 236)u/L,and statistically significant difference existed between the two groups(P 0.05). Conclusion Interventional heated-Lipiodol infusion combined with heated-Lipiodol injection into the tumor can more strongly inhibit the VX2 liver cancer than conventional transhepatic arterial infusion of 3 ml room-temperature(25℃) Lipiodoldoes in experimental rabbit models.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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