Title: The Relationship of Survivin Protein Expression with Carcinogenesis and Progression of Gastric Carcinoma—A Study by Tissue-microarray
Abstract: Objective To explore the relationship of survivin protein expression with the molecular mechanism of carcinogenesis and progression of gastric carcinoma.Methods Two blocks of tissue microarray were constructed,one containing 124 and another containing 101 small cylindrical samples,1.0 mm each in diameter,from 96 cases of gastric carcinoma and the precancerous lesions.The immunohistochemical stainning method was used to detect the survivin protein expression.Results The positive rate of survivin gene encoding protein in gastric cancer tissues was significantly higher than those in adjacent normal mucosa,intestinal metaplasia and dysplasia(P0.01).The positive rate of survivin protein expression in tumors with metastases was statistically higher than that in tumors without metastasis(P0.05).The expression of survivin was not related to the clincopathological stage,histological classification,lauren′s type and gross type of gastric cancer(P0.05).Conclusions Tissue microarray is a new powerful technique with a conspicuous characteristic of small volume rich in information in the tumor investigation.Survivin gene locked-up in normal human tissues is activated and involved in tumorigenesis and progression of gastric cancers and survivin can be a ideal marker for early diagnosis of gastric carcinoma and the metastasis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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