Title: Testing of Urinary Microprotein,Blood Urea Nitrogen and Creatinine in Neonatal with Asphyxia and its Clinical Significance
Abstract: Objective To test the urinary microprotein,blood blood urea nitrogen(BUN) and creatinine(Cr),and investigate the significance of microprotein in the early diagnosis of kidney damage in asphyxial neonates.Methods Thirty neonates with asphyxia(15 mild cases and 15 severe cases) and 15 healthy newborns were as asphyxia group and control group,respectively.The fresh urine specimens were collected within 48 hours after birth and used to test the urinary microprotein:urine α1-microglobulin(α1-MG),β2-microglobulin(β2-MG),N-acetyl-β-D-amino-glucuronidase(NAG),transferrin(TRF),immunoglobulins(IgG);and the venous blood was sampled to test serum BUN and Cr.Results As compared with control group,urinary α1-MG(8.92±1.25)mg/L,β2-MG(3.06±1.62)mg/L and NAG(14.76±4.69)mg/L levels of mild asphyxia group increased,the difference had statistical significant(P﹤0.01);While urinary TRF(2.65±1.94)mg/L,IgG(7.39±1.88)mg/L,blood BUN(5.23±2.04)mg/L and Cr(64.22±25.11)mg/L levels had not statistical significant difference(P0.05) between the both group.The urinary α1-MG(12.55±2.44)mg/L,β2-MG(9.35±2.86)mg/L,NAG(29.64±7.43)mg/L,TRF(9.27±2.11)mg/L,IgG(11.97±3.57)mg/L,blood BUN(14.36±3.11)mg/L and Cr(120.78±42.19)mg/L levels of the severe asphyxia group were significantly higher(P0.01).As compared severe asphyxia group to mild asphyxia group:urinary α1-MG,β2-MG,NAG levels had not statistical significant difference(P0.05).TRF,IgG,blood BUN and Cr levels were significantly higher(P0.01).The positive rate of individual indicators were 80.0% for α1-MG,71.1% for β2-MG,64.4% for NAG,37.8% for TRF,40.0% for IgG,and significantly higher than that(24.4%) of BUN and Cr(P0.01).Conclusion There is a significant change in urinary microprotein and its positive rate was significantly higher than serum BUN and Cr.The urinary microprotein level can be used as early diagnostic indicators of kidney damage in neonates with asphyxia.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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