Title: The significance of urine α_1-microglobulin in renal injury when after neonatal asphyxia
Abstract: Objective To discuss the clinical significance of α1-microglobulin in Urine for estimating renal dysfunction induced by neonatal asphyxia. Methods 58 cases of neonatal asphyxia were divided into mild asphyxia group( 32 cases) , severe asphyxia group( 26 cases) according to Apgar score. 30 cases of healthy full-term newborns were choiced as a control group in the same period. The level of α1-MG in urine detected by immunoturbidimetric assay was compared with serum urea ( BUN) and creatinine( Cr) on the third day after birth. Results BUN,Cr and urine α1-MG in severe asphyxia group and the mild asphyxia group were higher than that in healthy control group,as while as the severe asphyxia group of BUN,Cr and urine α1-MG level was significantly higher than the mild asphyxia group,the difference were statistically significant( P 0.01) .Mild asphyxia group and the severe asphyxia group of urine α1-MG abnormal detection rate were significantly higher than those with abnormal serum BUN and Cr detection rates,the differences were statistically significant( P 0. 05 or P 0. 01) . Conclusion Urinary α1-MG was an sensitive indicator to evaluate renal dysfunction after neonatal asphyxia.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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