Title: Values of changes of serum procalcitonin and interleukin-6 levels in diagnosis of infection in premature infants
Abstract: Objective: To explore the values of changes of serum procalcitonin(PCT) and interleukin-6(IL-6) levels in diagnosis of bacterial infectious diseases and Ureaplasma urealyticum(UU) infection in premature infants. Methods: A total of 110 premature infants diagnosed and treated in the hospital were selected,and then they were divided into bacterial infection group(40 infants),control group(40 infants) and UU infection group(30 infants) according to discharge diagnosis; the levels of PCT,IL- 6,C- reactive protein(CRP) were detected at 6-12 hours after birth. Results: The serum levels of PCT,IL-6,and CRP in bacterial infection group increased significantly,compared with UU infection group and control group,there was statistically significant difference(P 0. 01); the serum levels of PCT and IL- 6 in UU infection group increased significantly,compared with control group,there was statistically significant difference(P 0. 01); the sensitivities of PCT and IL 6 were higher than that of CRP in the diagnosis of bacterial infection,but the specificities of PCT and IL 6 were lower than that of CRP; the sensitivity and specificity of IL 6 in the diagnosis of UU infection were not high. Conclusion: PCT and IL- 6 are helpful to early diagnose systemic bacterial infection of preterm infants with high sensitivity,which contributes to directing timely and reasonable application of antibiotics in clinic.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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