Title: Expression and Significance of claudin-4 and PTEN in Endometrial Carcinoma
Abstract: Objective To investigate the expression and significance of claudin-4 and PTEN in endomentrioid adenocarcinoma.Methods Immunohistochemistry was applied to detect the expression of claudin-4 and PTEN in 75 cases of endomentrioid adenocarcinomas、35 dysplasias and 28 proliferating endometria.Results From proliferative endometrium、endometrial dysplasia to endometrial the positive expression of claudin-4 increased gradually.There was a significant difference between groups(P0.05).The positive expression of PTEN in three groups showed an increasing trend.The difference was significant(P0.05).The overexpression of claudin-4 was correlated to myometrialinvasion(P0.05),but not to histological grade invasion(P0.05),histological grade pathologic stage lymph node metastasis nor histological type;the hypoexpression of PTEN was correlated to myometrialinvasion(P0.05),not to those of the others.Negative correlation was found between claudin-4 and PTEN(r=-0.36,P0.05).Conclusion Overexpression of claudin-4 may be involved in carcinogenesis and development of endometrioid adenocarcinoma,and hypoexpression of PTEN may contribute to these process.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot