Title: Expression of PTEN Protein and the Clinical Value of the Expression in Primary Breast Carcinoma
Abstract: Objective:To observe the clinical value of expression of PTEN gene protein for predicting biological behaviors and prognosis of breast cancer. Method: Immunohistochemistry(S-P method)was used to detect the expression of PTEN in forty-two cases of paraffin-embedded human breast cancer tissues, and forty cases of paraffin-embedded hyperplasia of mammary glands tissues. Results: The high expression rate of PTEN gene protein was less in breast cancer than in hyperplasia of mammary glands(P0.01). The expression of PTEN gene protein was not related with the tumor size, histological grade, clinical stage and postoperative recurrence; but the high expression rate was higher in the elder patients(more than 45 years)than in younger(less than 45 years). The high expression of PTEN was significantly inversely correlated with axillary lymph node metastasis(P0.01)and it was a positive relationship with estrogen receptor(P0.05). The high expression of PTEN in breast cancer was negatively correlated with distant metastasis(P0.05)and was an positive relationship with the survival rate of 5-year(P0.01).Conclusion:The abnormal expression of PTEN gene protein plays an important role in the development of primary breast carcinoma. It may be a predictor for biological behaviors and prognosis of breast cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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