Publication Information

{'id': 'https://openalex.org/W2160797588', 'doi': 'https://doi.org/10.1111/j.1365-2559.2009.03468.x', 'title': 'Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma', 'display_name': 'Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma', 'publication_year': 2009, 'publication_date': '2009-12-23', 'ids': {'openalex': 'https://openalex.org/W2160797588', 'doi': 'https://doi.org/10.1111/j.1365-2559.2009.03468.x', 'mag': '2160797588', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20102402'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2559.2009.03468.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S14376486', 'display_name': 'Histopathology', 'issn_l': '0309-0167', 'issn': ['0309-0167', '1365-2559'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032284402', 'display_name': 'Kiseok Jang', 'orcid': 'https://orcid.org/0000-0002-6585-3990'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ki‐Seok Jang', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103846395', 'display_name': 'Young Soo Song', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Young Soo Song', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103048503', 'display_name': 'Si‐Hyong Jang', 'orcid': 'https://orcid.org/0000-0002-7605-086X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Si‐Hyong Jang', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061910936', 'display_name': 'Kyueng‐Whan Min', 'orcid': 'https://orcid.org/0000-0002-4757-9211'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kyueng‐Whan Min', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063160169', 'display_name': 'Woong Na', 'orcid': 'https://orcid.org/0000-0001-9871-8835'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Woong Na', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001652670', 'display_name': 'Se Min Jang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Se Min Jang', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011081432', 'display_name': 'Young Jin Jun', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Young Jin Jun', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081821112', 'display_name': 'Kang Hong Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4575257', 'display_name': 'Hanyang University', 'ror': 'https://ror.org/046865y68', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4575257']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kang Hong Lee', 'raw_affiliation_strings': ['Surgery, College of Medicine, Hanyang University'], 'affiliations': [{'raw_affiliation_string': 'Surgery, College of Medicine, Hanyang University', 'institution_ids': ['https://openalex.org/I4575257']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101683635', 'display_name': 'Dongho Choi', 'orcid': 'https://orcid.org/0000-0002-1255-1964'}, 'institutions': [], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Dongho Choi', 'raw_affiliation_strings': ['Department of Surgery, College of Medicine, Soon Chun Hyang University, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, College of Medicine, Soon Chun Hyang University, Seoul, Korea', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004795750', 'display_name': 'Seung Sam Paik', 'orcid': 'https://orcid.org/0000-0002-8607-4072'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Seung Sam Paik', 'raw_affiliation_strings': ['Departments of Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.525, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.822073, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '56', 'issue': '2', 'first_page': '229', 'last_page': '239'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9898, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tensin', 'display_name': 'Tensin', 'score': 0.6929547}, {'id': 'https://openalex.org/keywords/tissue-microarray', 'display_name': 'Tissue microarray', 'score': 0.5958731}], 'concepts': [{'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.9800544}, {'id': 'https://openalex.org/C2779549131', 'wikidata': 'https://www.wikidata.org/wiki/Q83167294', 'display_name': 'Tensin', 'level': 5, 'score': 0.6929547}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.6460519}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6065028}, {'id': 'https://openalex.org/C193270364', 'wikidata': 'https://www.wikidata.org/wiki/Q17141925', 'display_name': 'Tissue microarray', 'level': 3, 'score': 0.5958731}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.55770135}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45932648}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.45600307}, {'id': 'https://openalex.org/C2781182431', 'wikidata': 'https://www.wikidata.org/wiki/Q356033', 'display_name': 'Adenocarcinoma', 'level': 3, 'score': 0.42007655}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3932221}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3872431}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33360732}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.26951164}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.18712875}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018256', 'descriptor_name': 'Adenomatous Polyps', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008198', 'descriptor_name': 'Lymph Nodes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012007', 'descriptor_name': 'Rectum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018256', 'descriptor_name': 'Adenomatous Polyps', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018256', 'descriptor_name': 'Adenomatous Polyps', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018256', 'descriptor_name': 'Adenomatous Polyps', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053843', 'descriptor_name': 'DNA Mismatch Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008198', 'descriptor_name': 'Lymph Nodes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008198', 'descriptor_name': 'Lymph Nodes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012007', 'descriptor_name': 'Rectum', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D012007', 'descriptor_name': 'Rectum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2559.2009.03468.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S14376486', 'display_name': 'Histopathology', 'issn_l': '0309-0167', 'issn': ['0309-0167', '1365-2559'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20102402', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.5, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1489145507', 'https://openalex.org/W1539489658', 'https://openalex.org/W1577838670', 'https://openalex.org/W1951189073', 'https://openalex.org/W1969095321', 'https://openalex.org/W1969183396', 'https://openalex.org/W1971135095', 'https://openalex.org/W1974102418', 'https://openalex.org/W1998038367', 'https://openalex.org/W1999125576', 'https://openalex.org/W2000749236', 'https://openalex.org/W2003176075', 'https://openalex.org/W2006492820', 'https://openalex.org/W2007112412', 'https://openalex.org/W2007275707', 'https://openalex.org/W2008463032', 'https://openalex.org/W2020416725', 'https://openalex.org/W2029219396', 'https://openalex.org/W2036553081', 'https://openalex.org/W2054894450', 'https://openalex.org/W2065128520', 'https://openalex.org/W2068427129', 'https://openalex.org/W2074473619', 'https://openalex.org/W2082277330', 'https://openalex.org/W2095659495', 'https://openalex.org/W2095804402', 'https://openalex.org/W2096008575', 'https://openalex.org/W2100589633', 'https://openalex.org/W2103685839', 'https://openalex.org/W2111062014', 'https://openalex.org/W2112785522', 'https://openalex.org/W2119186515', 'https://openalex.org/W2119581553', 'https://openalex.org/W2120091640', 'https://openalex.org/W2126122220', 'https://openalex.org/W2144469062', 'https://openalex.org/W2145211249', 'https://openalex.org/W2150233389', 'https://openalex.org/W2155515642', 'https://openalex.org/W2157191335', 'https://openalex.org/W2160340469', 'https://openalex.org/W2160595349', 'https://openalex.org/W2160886349', 'https://openalex.org/W2161810908', 'https://openalex.org/W2167523886', 'https://openalex.org/W2167846026', 'https://openalex.org/W2171435505', 'https://openalex.org/W2315075748'], 'related_works': ['https://openalex.org/W4298172496', 'https://openalex.org/W2896764561', 'https://openalex.org/W2407165303', 'https://openalex.org/W2374272643', 'https://openalex.org/W2357679775', 'https://openalex.org/W2352568601', 'https://openalex.org/W2186965932', 'https://openalex.org/W2056117715', 'https://openalex.org/W2046077454', 'https://openalex.org/W1996644622'], 'abstract_inverted_index': {'Jang': [0, 5, 11], 'K‐S,': [1], 'Song': [2], 'Y': [3, 15], 'S,': [4], 'S‐H,': [6], 'Min': [7], 'K‐W,': [8], 'Na': [9], 'W,': [10], 'S': [12, 24, 25], 'M,': [13], 'Jun': [14], 'J,': [16], 'Lee': [17], 'K': [18], 'H,': [19], 'Choi': [20], 'D': [21], '&': [22], 'Paik': [23], '(2010)': [26], 'Histopathology': [27], '56,': [28], '229–239': [29], 'Clinicopathological': [30], 'significance': [31], 'of': [32, 67, 81, 91, 117, 120, 147, 159, 167, 178, 262, 269], 'nuclear': [33, 92, 263], 'PTEN': [34, 47, 68, 93, 110, 179, 243, 257, 264], 'expression': [35, 95, 180, 188, 244, 265], 'in': [36, 78, 228, 238, 258, 273], 'colorectal': [37, 162, 278], 'adenocarcinoma': [38, 203], 'Aims:': [39], 'Tumour': [40], 'suppressor': [41], 'phosphatase': [42], 'and': [43, 63, 72, 101, 105, 129, 143, 164, 189, 208, 215], 'tensin': [44], 'homologue': [45], '(': [46, 211], ')': [48], 'is': [49], 'an': [50, 253], 'important': [51, 254], 'negative': [52], 'regulator': [53], 'for': [54, 109, 153, 175, 256], 'the': [55, 89, 160, 168, 248], 'PIP3/Akt': [56], 'signalling': [57], 'pathway': [58], 'that': [59, 234], 'promotes': [60], 'cell': [61], 'proliferation': [62], 'inhibits': [64], 'apoptosis.': [65], 'Inactivation': [66], 'by': [69], 'mutation,': [70], 'deletion': [71], 'promoter': [73], 'hypermethylation': [74], 'has': [75], 'been': [76], 'demonstrated': [77], 'a': [79, 114, 205, 223, 267], 'range': [80], 'cancers.': [82], 'The': [83], 'aim': [84], 'was': [85, 111, 181, 226, 235, 266], 'to': [86, 183], 'investigate': [87], 'whether': [88], 'loss': [90, 261], 'protein': [94, 187], 'correlates': [96], 'with': [97, 201, 230, 275], 'conventional': [98], 'clinicopathological': [99], 'parameters': [100], 'patient': [102], 'survival.': [103], 'Methods': [104], 'results:': [106], 'Immunohistochemistry': [107], 'staining': [108], 'performed': [112], 'on': [113], 'tissue': [115], 'microarray': [116], '19': [118, 135], 'samples': [119, 139], 'normal': [121, 136], 'colonic': [122, 137, 190], 'mucosa,': [123], '14': [124, 148], 'adenomatous': [125, 149], 'polyps,': [126], '482': [127, 161], 'adenocarcinomas': [128, 163], '56': [130, 169], 'metastatic': [131, 170], 'lymph': [132, 171], 'nodes.': [133], 'All': [134], 'mucosa': [138], '(100%)': [140], 'were': [141, 151, 173], 'positive': [142, 152, 174], '12': [144], '(85.7%)': [145], 'out': [146], 'polyps': [150], 'PTEN.': [154, 176], 'However,': [155], 'only': [156], '241': [157], '(50.0%)': [158], '26': [165], '(46.4%)': [166], 'nodes': [172], 'Loss': [177], 'related': [182], 'defective': [184], 'mismatch': [185], 'repair': [186], 'localization': [191], 'rather': [192], 'than': [193], 'rectal': [194], 'localization.': [195], 'On': [196, 220], 'univariate': [197], 'survival': [198, 210], 'analysis,': [199, 222], 'patients': [200, 229, 274], 'PTEN−': [202], 'revealed': [204], 'poor': [206, 270], 'overall': [207], 'disease‐free': [209], 'P': [212, 216], '=': [213, 217], '0.030': [214], '0.046,': [218], 'respectively).': [219], 'multivariate': [221], 'significant': [224], 'difference': [225], 'observed': [227, 237], 'stage': [231, 276], 'II': [232, 277], 'cancer': [233], 'not': [236], 'other': [239], 'stages.': [240], 'Conclusions:': [241], 'Nuclear': [242], 'gradually': [245], 'decrease': [246], 'during': [247], 'normal–adenoma–adenocarcinoma–metastasis': [249], 'sequence,': [250], 'which': [251], 'suggests': [252], 'role': [255], 'carcinogenesis.': [259], 'Moreover,': [260], 'marker': [268], 'clinical': [271], 'outcome': [272], 'cancer.': [279]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160797588', 'counts_by_year': [{'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-24T13:27:47.598677', 'created_date': '2016-06-24'}