Title: Effect of Qubi Recipe on the vascular generate regulatory factors in synovium of collagen-induced arthritis rats
Abstract: Objective: From the perspective of synovial angiogenesis, to investigate the mechanism of Qubi Recipe in the treatment of rheumatoid arthritis(RA). Methods: Twelve male SD rats were randomly selected as blank control group, and 60 male SD rats were established as experiment arthritis rat model by subcutaneous injection of Ⅱ collagen and non-complete Freunds adjuvant. After 15 days, 60 CIA rats were randomly divided into model group, tripterygium glycosides group, Qubi Recipe high and low-dose groups. The rats in the treatment groups were administered intragastrically every day, for 4 weeks. The changes offins-like tyrosine kinase(FLT-4) and fetal liver kinase receptor(FLK-1) on synovial tissues in knee were detected by immunohistochemistry method. Results: Compared with the blank control group, the expression of FLK-1 and FLT-4 were obviously increased(P0.01). The level of FLK-1 and FLT-4 were decreased in tripterygium glycosides group and Qubi Recipe high-dose group(P0.01). Moreover, the expression of FLK-1 in Qubi Recipe high-dose group was signii cantly lower than those in tripterygium glycosides group(P0.05). Conclusion: The treatment effect of Qubi Recipe for RA is correlated with theinhibition of angiogenesis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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