Title: Effect of added Xijiaodihuang decoction on VEGF level in joint synovial tissue s of CIA model rats
Abstract: Objective To explore the therapeutic effect of the Added Xijiaodihuang Decoction for rheumatoid arthritis by determining the levels of vascular endothelial growth factor(VEGF) in the joint synovial tissue of rats during the derivation of collagen-induced arthritis(CIA).Methods SD rats were used to establish type II CIA rat model.VEGF levels were determined by real-time fluorescence quantitative RT-PCR at the 42th day after the induction in the rats of control,model and experimental group.Results VEGF level in the model group was obviously higher than that in control group,and the level in the experimental group was much lower than that in the model group.Conclusion Added Xijiaodihuang Decoction showed a role of reducing VEGF level in joint synovial tissue of CIA model rats and may have certain therapeutic effect for the acute stage of RA.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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