Title: EFFECTS OF TOTAL SAPONIN OF RHIZOMA DIOSCREAE NIPPONICAE ON ANGIOGENESIS IN SYNOVIAL MEMBRANE OF CIA RATS
Abstract: Objective:To investigate effects of total saponin of Rhizoma Dioscreae Nipponicae(RDN) on angiogenesis and expression of vascular endothelial growth factor(VEGF) in synovial membrane of collagen-induced arthritis(CIA) rats.Methods:42 Wistar rats were randomly divided into 7 groups(n=6): normal controlgroup(A),CIA model group(B),Tripterygium group(C),RDN high dose group(D),RDN middle dose group(E),RDN low dose group (F) and Diosgenin group(G).Rats in B-G group were established CIA rat model;then the rats in C-G group were lavaged with corresponding medicine for 21 days.Immunohistochemical staining was used to detect MVD and VEGF expression in synovial membrane.Results:MVD and VEGF expression in synovial membrane of CIA rats were obviously higher than normal control rats(P 0.01);MVD and VEGF expression in synovial membrane of rats in each treatment group were obviously lower than CIA model rats(P 0.01);moreover,there had no obvious differences between each treatment group(P 0.05).Conclusions:RDN can inhibit angiogenesis in synovial membrane by down regulating VEGF expression.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot