Title: Clinical study on hydrochlorothiazide combined with valsartan in treatment of elderly hypertension
Abstract: Objective To investigate the effect of hydrochlorothiazide combined with valsartan in the treatment of elderly hypertension. Methods Collecting 96 cases suffered from elderly hypertension from July 2011 to June 2014 in Xinhua Hospital Affiliated to School of Medicine of Shanghai Jiaotong University, which were randomly divided into treatment(48 cases) and control(48 cases) groups. The patients in the control group were po administered with Valsartan Capsule, 80 mg/d, while the patients in the treatment group were po administered with Hydrochlorothiazide Tablets, 12.5 mg/d, and other treatment was the same as the control group. The patients in the two groups were treated for 2 months. After the treatment, the treatment efficacy was evaluated, while SBP, SBPV, DBP, DBPV, control rate of MBPS, NO, and endothelin were compared between the two groups. Results The efficacies in the control and treatment groups were 97.92% and 83.33%, respectively, and there were differences between the two groups(P 0.05). After the treatment, SBP, SBPV, DBP, DBPV, and endothelin in the two groups were significantly reduced, while NO were significantly increased, and the difference was statistically significant before and after the treatment in the same group(P 0.05). And after the treatment, those observational indexes were improved better than those in the control group, and there was significant difference between the two groups(P 0.05). The control rate of MBPS in the treatment group was 93.75%, and in the control group was 81.25%, and there was significant difference between the two groups(P 0.05). Conclusion Hydrochlorothiazide combine with valsartan has a good clinical effect in the treatment of elderly hypertension, and can significantly reduce the blood pressure and circadian variation of blood pressure, which may be associated with regulating the level of NO and endothelin.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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