Title: Expressions of Ets-1 mRNA and protein in esophageal squamous cell carcinoma
Abstract: Objective To detect the expressions of transcription factor Ets-1 mRNA and protein in the various lesions of esophagus.Methods The expression levels of Ets-1 mRNA and protein were detected in 62 cases of esophageal squamous cell carcinoma(ESCC),31 cases of dysplasia and 62 cases of normal esophageal tissues by in situ hybridization and immunohistochemistry. Results Positive expression rates of Ets-1 mRNA and protein were gradually increased from normal esophageal tissues, atypical hyperplasia to ESCC tissues,and there were significant differences among them(P0.01).The positive expression of Ets-1 mRNA increased with the tumor grade,but there was no statistically significant(P0.05),it was positively correlated with infiltration and lymphatic metastasis of ESCC(P0.05).The expression of Ets-1 protein was positively correlated with tumor grade and infiltration and lymphatic metastasis of ESCC(P0.05).The expressions of Ets-1 mRNA and protein in ESCC were positively related(r = 0.343,P0.05).Conclusion Enhancement expression of Ets-1 gene may be an early event in the development of ESCC and Ets-1 may be an objective indicator to evaluate the invasiveness and metastasis of ESCC.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot