Title: Expression of DDR1 in esophageal squamous cell carcinoma tissue
Abstract: Objective:To study the expression of discoidin domain receptor1(DDR1) protein in esophageal squamous cell carcinoma(ESCC) tissues. Methods:The expression of DDR1 protein was detected by Western blotting in 40 cases of ESCC tissues,para-cancer tissues,and matched esophageal normal tissues,and their relation to clinical pathologic characteristics of esophageal cancer was analyzed. Results:The expressionof DDR1 in ESCC(1.201±0.348)were significantly higher than those in para-cancer tissues(0.640±0.323)and normal esophageal tissues(0.551±0.413). The positive expression rate and relative content of DDR1 in ESCC were correlated with degrees of differentiation、lymphnode metastasis and invasion depth of carcinoma (P0.05). Conclusions:These findings indicate that DDR1 protein may be closely associated with the incidence and development of ESCC. The upregulation of DDR1 is marked during the metastasis of ESCC.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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