Title: Effect of Qianghuo Dihuang Decoction on the Serum Levels of TNF-α,IL-1β and IL-6 in Rats with Freund's Complete Adjuvant-induced Rheumatoid Arthritis
Abstract: Objective:To observe the effect of Qianghuo Dihuang Decoction on the serum levels of tumor necrosis factor alpha(TNF-α),interleukin-1β(IL-1β)and interleukin-6(IL-6)in rats with Freund's complete adjuvant-induced rheumatoid arthritis,and to explore the possible mechanism of Qianghuo Dihuang Decoction in the treatment of rheumatoid arthritis, so as to provide experimental basis for the application of Qianghuo Dihuang Decoction in clinic.Methods:The adjuvant arthritis rat model was established.SD rats were randomly divided into normal control group,model group,Qianghuo Dihuang Decoction group and methotrexate group.Intragastric administration method was adopted in the treatment.Enzymelinked immunosorbent assay was used for detection of the serum levels of TNF-α,IL-1βand IL-6in AA rats.Results:The serum levels of TNF-α,IL-1βand IL-6in model group were higher than those in normal control group(P0.01).After treatment,the serum levels of TNF-α,IL-1βand IL-6in Qianghuo Dihuang Decoction group and methotrexate group were lower than those in the model group(P0.01).There was no significant difference between Qianghuo Dihuang Decoction group and the methotrexate group in the serum levels of TNF-α,IL-1βand IL-6(P ﹥0.05).Conclusion:Qianghuo Dihuang Decoction can inhibit the abnormal secretion of TNF-α,IL-1βand IL-6in AA rats,so that it can prevent the development of immune inflammation in AA rats.Our experimental results showed that the effect of Qianghuo Dihuang Decoction on serum levels of TNF-α,IL-1βand IL-6is the possible mechanism in the treatment of RA.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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