Title: Influnce of Dangguiniantong Decoction on IL-1β And TNF-α of Rats with Acute Gouty Arthritis
Abstract: Objective:To observe the influnce of Dangguiniantong Decoction on IL-1β and TNF-α of rats with Acute Gouty Arthritis.Methods:60 male wistar rats were randomly divided into six groups:control group,model group,colchicine group,and three treatment groups with Dangguiniantong Decoction of high,medium and low dosage.Use the treatment of Dangguiniantong Decoction to the model established by injecting monosodium urate(MSU) solution into ankle cavities of the rats,and compare with colchicine.Serum levels of IL-1β and TNF-α of rats in all groups were detected with ABC-ELISA.Results:Serum IL-1β and TNF-α of rats in model group were higher than that in control group(P0.05).Serum levels of IL-1β and TNF-α of rats in colchicine group,and three treatment groups with Dangguiniantong Decoction of high,medium and low dosage were lower than that in model group(P0.05).Conclusion:The therapeutic effect of Dangguiniantong Decoction on Acute Gouty Arthritis may be associated with decrease of IL-1β and TNF-α.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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