Title: Effects of glyoxal on the serum level of lipid peroxide and activity of superoxide dismutase in mice
Abstract: Objective To study the possible mechanism of glyoxal poisoning in mice.Method Forty mice were divided into trial and control groups.Mice in trial group were exposed to varied doses of glyoxal,1.29 mmol/kg,2.58 mmol/kg and 5.16 mmol/kg,respectively,by intraperitoneal injection once daily for 30 days.Serum and tissue levels of malonyl dialdehyde(MDA)were measured with thiobarbiturate colorimetry and activity of superoxide dismutase(SOD)in the whole blood and tissues were measured with xanthine oxidase method.Result Level of MDA in the kidney of the mice exposed to high-dose-glyoxal increased significantly than that in the control mice.There was no significant difference in the other indicators measured between the exposed and control mice.Also,there was no significant difference in activity of SOD in the whole blood,liver and kidney between the exposed and control mice.Conclusion Glyoxal could increase content of MDA in the kidney of mice exposed to glyoxal,suggesting it could cause oxidative injury in renal tissue of mice.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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