Title: [Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice].
Abstract: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.
Publication Year: 2014
Publication Date: 2014-05-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 2
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