Title: The Effects of Simvastatin Probucol and Captopril on the Intima Media Thickness of Carotid and Femoral Arteries
Abstract: Aim To evaluate the therapeutic effects of simvastatin probucol and captopril on the atherosclerotic plaques with high-frequency ultrasound imaging. Methods 102 patients with atherosclerosis were randomly divided into 4 groups: the simvastatin group, the probucol group, the captopril group, and the placebo group. Both sides of carotid and femoral arteries were detected with a 4~10 MHz transducer and intima-media thickness (IMT)were determined. IMT of normal segment of each artery was defined as IMTa, the maximal IMT of each artery as IMTb, the mean maximal IMT of 4 arteries as IMTc, the maximal IMTc of 4 arteries as IMTd. The systemic examinations were repeated in 3 years after treatments. Results After 3 years treatment IMT values increased significantly in the atherosclerosis arteries (P0.05). The change values of IMTa in control group (0.04±0.12 mm) was larger than that of the right carotid artery in probucol group (0.04±0.12 mm) and the left carotid artery(0.04±0.26 mm) and right femoral artery (0.03±0.23 mm)in simvastatin group (P0.05). The pregression values of IMTb and IMTc in simvastatin group and IMTb in all therapetic groups were singnificantly lowered than that of control group (P0.05). The pregression rates of IMTc in simvastatin group (0.17±0.12 mm)and captopril group (0.21±0.15 mm) were singnificantly lowered than that of control group (0.25±0.2 mm) (P0.01). The pregression value and rate of IMTd in all therapetic groups were significantly lower than that of control group (P0.05). Conclusions The drug theray can decrease the progression of atherosclerosis but had no effect on the normal segment of arteries. The high frequence ultrasound technique provides a reliable routine for monitoring progression or regression of atherosclerosis in carotid and femoral arteries.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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