Title: Investigation on the intervention effects of Simvastatin on the structure and function of carotid artery in patients with metabolism syndrome
Abstract: Objective:To measure the structure and function of carotid artery,and furtherly to investigate the effects of simvastatin on the carotid artery.Method:After selecting 85 patients with metabolism syndrome(MS),their body mass indexes,waist circumferences,blood lipids,fasting blood glucose,plasma hs-CRP were measured.The intima-media thickness(IMT) of the common carotid artery,the plaque index,the compliance of carotid artery,the distensibility of common carotid artery,carotid artery stiffness,wall surface and wall texture were examined using B-mode ultrasonography.All the parameters were meatured again after the patients were treated with sinvastatin for 4,24,and 48 weeks respectively,and were compared with the original parameters.Result:After treatment with simvastatin for 4 weeks,the plasma levels of LDL-C and hs-CRP decreased,and the compliance of carotid artery,the distensibility of common carotid artery and the carotid artery stiffness were improved significantly.But the IMT and the plaque index were not changed markedly.After treatment with simvastatin for 24 weeks,the plasma levels of LDL-C and hs-CRP decreased more significantly,and further imporvement was seen on the compliance of carotid artery,the distensibility of common carotid artery and the carotid artery stiffness.Among the improvements,the most important thing is that the IMT and plaque index were also improved.After treatment with simvastatin for 48 weeks,the changes on the plasma levels of LDL-C and hs-CRP were not apparent,but the IMT and plaque index could be further improved.Conclusion:Simvastatin can be used safely in patients with MS as a short,media or long-term treatment.The short-term treatment with simvastatin can improve the function of the carotid artery in patients with MS.The media and long-term treatment with simvastatin can also improve the structure of the carotid artery.But the underlying mechanisms need further investigation.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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