Title: Expression and significance of tumor metastasis associated 1 and suppressor gene KISS-1 in pancreatic cancer
Abstract: Objective To study the expression of tumor metastasis associated 1(MTA1) and suppressor gene KISS-1 in the pancreatic cancer and explores its relationship with the pathological indicators.Methods The immunohistochemical Envision two-step method was used to detect the MTA1 and KISS-1 protein expression in 36 cases of pancreatic cancer tissue and 10 cases of normal paracancer tissue.Results The positive expression rate of MTA1 in pancreatic cancer was 77.8%(28/36),which was significantly higher than the 20.0%(2/10) in the normal paracancer tissue(P 0.01);The positive expression rate of KISS-1 in pancreatic cancer was 90.0%(9/10),which was significantly lower than the 90.0%(9/10) in the normal paracancer tissue(P 0.01).The expression of both genes were unrelated to the patient age,gender and tumor location(P 0.05),but related to the differentiation degree of cancer tissue,lymph node metastasis and clinical stage(P 0.05).In the pancreatic cancer tissue,the expression of MTA1 and KISS-1 were negatively correlated with each other(r =-0.533,P 0.01).Conclusion MTA1 and KISS-1 are related to the occurrence,invasion and metastasis of pancreatic cancer and therefore are expected to become important biological indicators in the diagnosis and treatment of pancreatic cancer.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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