Title: The Effect of Xuefuzhuyu Decoction and Its Seperated Decoction on JNK_1 mRNA of Atherosclerosis Vascular Smooth Muscle Cells
Abstract: Objective:To study the effect of Xuefuzhuyu decoction and its seperated decoction on JNK1 mRNA of atherosclerosis vascular smooth muscle cells.Methods:The atherosclerosis model rabbits were prepared by fed high cholesterol diet,used the method of hybridization in situ to detect the expression of JNK1 mRNA.Results:The model group compared with the blank group,the expression of JNK1 mRNA were remarkably increased,the difference was of statistical signifycance(P0.01).The medicine groups compared with the model group,the expression of JNK1 mRNA in Xuefuzhuyu decoction group and Sinisan decoction group were increased,the difference was of statistical signifycance(P0.01,P0.05);Taohongsiwu decoction group was not of statistical signifycance(P0.05).Conclusion:Xuefuzhuyu decoction and its seperated decoction are effective to increased the expression of JNK1 mRNA.It maybe the one of the mechanism of anti-proliferation in atherosclerosis vascular smooth muscle cells.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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