Title: Effects of"Shuxin Qufeng Decoction"on Atherosclerosis in Rats
Abstract: Objective:To investigate the effects ofShuxin Qufeng Decoctionon atherosclerorosis in rats.Methods: Sixty SD rats were randomly divided into five groups:control group,model group,low-dosageShuxin Qufeng Decoctiongroup, high-dosageShuxin Qufeng Decoctiongroup,and simvastatin group,twelve rats in each group.After 8 weeks of different treatments, the blood lipid,AngiotensinⅠand AngiotensinⅡwere delected;the morphology of thoracic aortic intima was observed;the expressions of MCP-1 and P-selectin were tested by immunohistochemistry;the mRNA expressions of MCP-1 and Ps were detected by RT-PCR method.Results:Shuxin Qufeng Decoctioncould reduce the level of blood low density lipoprotein,raised the level of blood high density lipoprotein,reduced the level of AngiotensinⅡ,regulated the activation of blood platelet and chemokine MCP-Ⅰprotein expressions;the over-expressions of the mRNA of MCP-1 and P-selectin in transcription were reduced.Conclusions:Shuxin Qufeng Decoctioncan prevent atherosclerosis possibly by reducing the activation of blood platelet and inhibiting the expression of inflammatory facors.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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