Title: Buyanghuanwu Decoction on Expression of MMP-9 in AS Model Aorta
Abstract: Objective:Making use of atherosclerosis(AS)rat model induced by high fat diet,we have studied the effect of Buyanghuanwu Decoction on AS rat model,meanwhile,investigate the mechanism on protein level.Methods:The AS rats were divided into Buyanghuanwu Decoction group,Ligustrazine group,control group and blank group after model successing.The expression level of Matrix Metalloproteinase-9(MMP-9) and blood-lipid were detected.Results:High fat diet could induce atherosclerosis in rat.Compairing with normal control group,the level of TC,TG,LDL of model group was increased.There was high positive expression of MMP-9 in atherosclerosis model aorta.Compairing with ligustrazine therapy group and model group,the expression of MMP-9,the level of LDL of Buyanghuanwu Decoction group were decreased significantly.Conclusion:Representative formula of Qi-Benifiting and Blood-Activating Chinese medicinal herbs Buyanghuanwu Decoction have effect of down-regulating the expression of MMP-9,lowering the level of blood-lipid in rat model,so that have effect of againsting atherosclerosis.Down-regulating the expression of MMP-9 may be one of the mechanisms of againsting atherosclerosis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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