Title: YuxinAnshen pills' Effect on Blood Stasis and Acute Myocardial Ischemia:a random trial of model rats
Abstract: Objective:To observe the improving effects of Yuxinanshen pills on hemorheological changes in rats and on pituitrin-induced acute myocardial ischemia of rats.Methods:All Wistar rats were randomLy divided into five groups included the Yuxinanshen pills group in which the blood stasis rats and acute myocardial ischemia rats were induced successfully by epinephrine-ice water bath and pituitrin respectively,and various indicators of hemorheology were measured in stasisrats;furthermore,in acute myocardial ischemia rats,changes of heart rate and serum concentration of myocardial enzymogram(Creatine Kinase,CK;Creatine Kinase-MB,CK-MB;α-Hydroxybutyric acid,HBDH;Malonaldehyde,MDA;Aspartate aminotransferase,AST;Lactic Dehydrogenase,LDH;Nitric Oxide,NO;and Super-Oxide Dismutase,SOD) at different time were observed.Results:The whole blood viscosity(ηb),whole blood reduced viscosity(ηr),plasma viscosity(ηp) and red cell aggregation index(AI) in different shear had decreased after administrated different dose of Yuxinanshen pills in stasisrats.For those rats with pituitrin-induced acute myocardial ischemia,although decreased heart rate cannot be improved evidently after administrated Yuxinanshen pills,the increase of serum level of CK,CKMB,HBDH,MDA,AST and LDH and the decrease of plasma NO and SOD can be found after administrated Yuxinanshen pills.Conclusions:Yuxinanshen pills can obviously decrease blood viscosity of rats and improve their property of hemorrheology,and it also can improve the serum condition of rats with pituitrin-induced acute myocardial ischemia.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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