Title: Research on the Related Factors at Different Stages of Blood Stasis Syndrome of TCM for Cerebrovascular Disease
Abstract: Objective To investigate the changes of blood system and endothelial cell active factors at different stages of blood stasis syndrome of TCM for cerebrovascular disease.Methods To define the cerebral atherosclerosis (CAS) as the period before blood stasis,the acute cerebral infarction (ACI) as acute blood stasis period,the recovery phase of stroke (RPS) as chronic blood stasis period, and to observe the changes of hemorheology and endothelial active factors (tPA?PAI?PGFlα?TXB2?ⅧR:Ag?Fn),to observe the anti-lipid peroxidation (SOD?GSH?CAT?MDA) and the concentration of some microelements (Cu?Fe?Se?Zn).Results (1)The blood viscosity?plasma viscosity?blood reduced viscosity?HCT and ratio of K (ESR) increased in CAS patients during the period before blood stasis, while the concentration of fibrinogen increased,and the activity of tPA decreased while the activity of PAI increased. After VOT the concentration of tPA increased obviously, while the concentration of PAI decreased. (2)The decrease of fibrinolytic system's activity was shown frequently in the three types of TCM-syndrome-stagnancy of vital-energy and blood stasis, evil-wind sputum and blood stasis, evil-heat sputum and hollow-organ sthenia syndromes, which takes evil-sputum and blood stasis as their main pathogenesis. The activity of tPA decreased significantly in the three types of ACI patients. The disorder of PGI 2-TXA 2 system and the decrease of PGF1α were shown frequently in the types of wind-stirring of Yin-deficiency and hyperactivity of Liver-Yang.(3)In chronic blood stasis period (the RPS patients), the concentration of MDA increased significantly in the types of hyperactivity of Liver-Yang, evil-heat sputum and hollow-organ sthenia, vital-energy deficiency and blood stasis syndromes, while the concentration of plasma SOD and GSH decreased obviously. The concentration of CAT decreased in the types of evil-heat sputum and hollow-organ sthenia and wind-stirring of Yin-deficiency. The selenium in blood serum decreased significantly in the types of hyperactivity of Liver-Yang, evil-heat sputum and hollow-organ sthenia, wind-stirring of Yin-deficiency and vital-energy deficiency and blood stasis syndromes. The concentration of GSH was the main factor which affects the concentration of selenium in blood serum. The concentration of zinc in blood serum decreased in the latter two types. The type of wind-stirring of Yin-deficiency was accompanied by the decrease of copper in blood serum, while the type of vital-energy deficiency and blood stasis was accompanied by the increase of iron in blood serum.Conclusions The type of blood stasis of TCM syndrome in cerebrovascular diseases had three different periods which were period before blood stasis, acute blood stasis period and chronic blood stasis. there were different pathological basis in three periods.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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