Title: The Expression and Significance of Tumor Necrosis Factor Receptor p55 and p75 in Thyroid Carcinoma Tissues
Abstract: Objective:To investigate the expression of tumor necrosis factor receptor(TNFR) p55 and p75 in thyroid carcinoma and their relations with clinicopathologic factors,so as to study the role and significance of the two receptors in thyroid carcinoma tissues.Methods:SP immunohistochemical method was used to determine their expression of TNFRp55 and p75 in 41 specimens of thyroid cancerous tissues.Simultaneously 9 thyroid adenomas tissues and 7 normal thyroid tissues adjacent to the adenoma were regarded as the control group.Results:①The levels of TNFRp55 and p75 in thyroid carcinoma were significantly higher than those in the control group(P0.001),but there was no significant difference for p55 and p75 between thyroid adenomas and normal thyroid tissues(P0.001).②Their expression levels of TNFRp55 and p75 were closely related to pathologic histological types: they were higher in papillary thyroid carcinoma than those in follicular thyroid carcinomas(TNFRp55,P0.05;TNFRp75,P0.001),but they were not related to other clinicopathologic factors such as sex,age,the depth of invasion,lymphnode metastasis and the size of tumor.③Two types of TNFR turned out to have positive relations in thyroid carcinoma tissues(r=0.77,P0.001).Conclusion:TNFRp55 and p75 are highly synergetic expressed in thyroid carcinoma tissues,which are involved in the generation and development of the carcinogenesis of thyroid carcinoma,controlling the spread of papillary thyroid carcinoma.They are one of the pathological indexes for diagnosis and differential diagnosis of thyroid carcinoma,but are probably not used to assess the biological behaviors and prognoses of thyroid carcinoma.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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