Title: The Role of Vascular Endothelial Growth Factor C and Chemokine Receptor CCR7 Expression in the Development of Lymph Node Metastasis in Colon Carcinoma
Abstract: Objective To study the expression of vascular endothelial growth factor C(VEGF-C) and chemokine receptor CCR7 in colon carcinoma and to investigate the associations with lymph node metastasis of colon carcinoma and their values in predicting lymph node metastasis.Methods Hybridization in situ and immunohistochemical double staining technique were used to investigate expression of VEGF-C mRNA?CCR7mRNA and lymphatic vessel density(LVD) in 41 cases of colon carcinoma,41 cases of normal colon mucosa.Results The Positive expression of VEGF-C mRNA and CCR7mRNA were 34.15%(14/41) and 58.54%(24/41) in 41 cases of colon carcinoma.The expression of VEGF-C mRNA ?CCR7 mRNA and LVD were significantly correlated with lymph node metastasis(P0.05).Conclusion Our study demonstrates that VEGF-C mRNA and CCR7 mRNA was involved in the colon carcinoma lymph node metastasis.The combined examination of VEGF-C and CCR7 expression in endoscopic biopsy specimens may be useful in predicting lymph node metastasis of colon carcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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