Title: The relationship among serum homocysteine, age, type of coronary heart disease and the branches of coronary arteriopathy
Abstract: Objective To investigate the significance of homocysteine (Hcy) in pathogenesis of coronary heart disease (CHD) and the relationship among serum homocysteine , age, type of CHD and the branches of coronary arteriopathy. Methods In a cross sectional test, serum Hcy levels of 166 old cases (age≥60 years) and 161 non old cases(age60 years) undergoing coronary arteriography and 63 healthy people were measured using high-performance liquid chromatography(HPLC)with fluorescence detection. Results Coronary atherosclerosis was correspondingly related with male, aging and elevated Hcy level. The mean serum Hcy level was significantly lower in old CHD patients 〔(17.63±7.12)μmol/L〕 than in non old CHD patients 〔(20.82±13.31)μmol/L 〕, P0.05. The mean serum Hcy level was higher in old CHD patients with 2 and 3 branches of arteripathy than 1 branch of arteriopathy, P0.05. Hcy level was similar in old CHD patients between different CHD types. Conclusions The results show that elevated Hcy level,male and aging were independent risk factors in the development of atherosclerosis. Age has the definite impact on Hcy level. There is relationship between Hcy level and the branches of coronary arteriopathy in old CHD patients. There is relationship between Hcy level and the type of CHD in non old CHD patients.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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