Title: Changes and Clinical Significance of Urinary NGAL and KIM-1 in Patients with Diabetic Nephropathy
Abstract: Objective To explore the changes of urinary NGAL and KIM-1 in patients with diabetic nephropathy and their clinical significance.Methods 70 patients with type 2 diabetes mellitus(T2DM) admitted to our hospital were divided into normal albuminuria group(NA group,28 cases),micro albuminuria group(MI group,22 cases) and macro albuminuria group(MA group,20 cases) according to albumin-to-creatinine ratio(ACR).Meanwhile,23 non-diabetic and non-nephropathy patients were involved as control group.The levels of NGAL and KIM-1 of the four groups were detected by ELISA and were then analyzed.The correlation of urine NGAL/urine Cr,urine KIM-1/urine Cr and ACR/urine Cr was also analyzed.Results(1) The blood glucose levels of NA group,MI group and MA group were all significantly higher than that of the control group(P all0.05).The GFR level of the MA group was significantly lower than the other three groups(P all0.05).The SCr level of the MA group was significantly higher than the other three groups(P all0.05).The urine NGAL/urine Cr and urine KIM-1/urine Cr in MI group and MA group were significantly higher than the control group and NA group(P all0.05).(2) The urine NGAL/urine Cr were positively correlated with ACR/urine Cr(r=0.864,P0.001),and the urine KIM-1/urine Cr were also positively correlated with ACR/urine Cr(r=0.835,P0.001).Conclusion NGAL and KIM-1 may play an important role in the occurrence and development of DN,and urine NGAL and KIM-1 might be predictors of the severity of DN.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot