Title: Clinical Significance of Protein Expression of ThreeDrug Resistant Genes in Patients with Breast Cancer
Abstract: Objective: To investigate clinical significance of drug resistant genes P glycoprotein(P gp), glutathoine S transferase Pi (GSTπ), and topoinsomerase Ⅱα (TopoⅡα) expression in the patients with breast cancer. Methods:P gp,GSTπ,and TopoⅡα protein expressions were determined using immunohistochemistry assay.The laboratory results and clinical follow up data were analyzed by epidemiological statistics. Results:P gp and TopoⅡα protein expressions were significantly associated with axially lymph node metastasis and distant metastasis. Both P gp and GSTπ positive expressions were related to preoperative chemotherapy. Univariate analysis showed that P gp and GSTπ expression could predict the overall survival(P=0.0001 and 0.0515, respectively), but no similar results were obtained by multivariate analysis. Conclusion:Both P gp and TopoⅡα expressions were closely related to breast cancer metastasis. Preoperative chemotherapy could induce drug resistance in breast cancer. But P gp, GSTπ, and TopoⅡα protein expressions cannot serve as an independent index for judging prognosis in breast cancer patients, respectively.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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