Title: Expression of drug resistance related genes in breast cancer tissues and its clinical significance
Abstract: OBJECTIVE:To explore the mechanisms of drug resistance in breast cancer patients and the clinical biological datas.The correlations among five kinds of multidrug resistance(MDR)related markers were also analyzed.METHODS:The expressions of P-glycoprotein(P-gP),Glutsthione-S-transferases-π(GST-π),multidrug related protein(MRP),O6-methyl-guanine-DNA methyltransferase(MGMT)and lung resistance protein(LRP)were studied in 64 samples of breast cancer by flow cytometry and their clinical significance was analyzed by SPSS 10.0.RESULTS:There were expressions of P-gp,GST-π,LRP,MGMT,MRP in breast cancer tissues.The expressions of P-gP and GST-π were higher in petients with lymph node metastasis(P=0.007 and P=0.031,respectively).The expression of MGMT was higher in patients of ages 50,P=0.018.The levels of GST-π,MRP and MGMT were higher in patients with larger tumor size(P=0.042,0.000 and 0.015,respectively).The expressions of five kinds of MDR genes had no significant differences between estrogen receptor(ER)positive and ER negative groups and also between progesten receptor(PR)positive and PR negative groups.Among five kinds of MDR related markers,there were positive correlations between P-gP and GST-π expressions and between LRP and MRP expressions(r=0.66,P=0.000,r=0.434,P=0.004,respectively).CONCLUSIONS The expressions of drug resistance proteines in breast cancer tissues are related to larger tumor size,age 50,lymph node metastasis,which may suggests that the higher expression of MDR genes may be a poor prognostic factor in breast cancer patients.There are coexpressions among five kinds of MDR related proteins.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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