Title: The Relationship between 4.1B Protein Expression and Development of None Small Cell Lung Cancer
Abstract: Objective:To study the association of 4.1B protein expression with the development of None Small Cell Lung Cancers(NSCLCs.)Methods:To detect 4.1B expression with Immunohistochemistry(IHC),tissues were collected from 166 cases of NSCLC who were surgical-resected and paraffin-embedded.The Association of the protein expression with the development of NSCLC was analyzed too.Results:4.1B protein of 26 cases expressed on the cell membrane,69 casesshowed absence of 4.1B protein expression.4.1B protein of 71caseswas detected diffusely in the cytoplasm.A total of 140 cases(84.34%) had abnormal expression of 4.1B protein including these tumors with cytoplasm expression.The positive rate of 4.1B protein membrane expression in the group which tumor maximum diameter was≤3cm was higher than that in the group which tumor maximum diameter was3cm.The positive rate of 4.1B protein expression in the group NSCLC hasn't metastazed was higher than that in the group NSCLC has metastazed.The positive rate of 4.1B protein expression in the groupⅠ、Ⅱstage was higher than that in the group Ⅲ、Ⅳstage.The rate of 4.1B protein cytoplasm expression has no significant difference between the group which tumor maximum diameter was≤3cm and the group which tumor maximum diameter was3cm,between the group NSCLC hasn't metastased and the group NSCLC has metastased,and between the group ofⅠ,Ⅱstage and the group of Ⅲ,Ⅳstage.Conclusions:Loss of 4.1B protein expression and mislocalization of 4.1B protein exist in NSCLC tissues.4.1B protein expressed at cell membrane may suppress the development of NSCLC.Loss of 4.1B protein expressed at cell membrane may promote the development of NSCLC.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot