Title: Expression and Significance of NF-κBp65 and MMP-9 in Non-Small Cell Lung Cancer
Abstract: Objective:To investigate the clinical significance of protein expressions of nuclear factor kappa B(NF-κB) and MMP-9 in non-small cell lung cancer(NSCLC).Methods:The expression levels of NF-κBp65 and MMP-9 protein were detected by immunohistochemical staining in NSCLC(n=95) and adjacent normal lung tissues(n=27).Results:(1)The expression rate of NF-κBp65 protein was significantly higher in NSCLC(44.2%) than that of adjacent normal lung tissue(22.2%,χ2 =4.26,P 0.05).(2)There were significant differences in expression levels of NF-κBp65 protein between the different tissue typing,clinical classification,clinical stage and metastasis(P 0.05 or P 0.01),but there were no significant differences in expression levels of NF-κBp65 protein between the different age,gender and tumor size in NSCLC patients(P 0.05).(3)The positive expression rate of MMP-9 protein was significant higher in patients of late-stage(Ⅲ) than that of early-and mid-stage(I-II)(P 0.05).The expression rate of MMP-9 was higher in adenosquamous carcinoma than that of quamous cell carcinoma(P 0.01),and the positive rate was gradually increased with the lower degree of tumor differentiation(P 0.05).The expression rate of MMP-9 was not significantly correlated with the age,gender and tumor size in NSCLC patients(P 0.05).(4) There was obviously positive correlation between NF-κBp65 and MMP-9(rs=0.217,P 0.05),and both were correlated with the metastasis.Conclusion:The results indicate that NF-κBp65 and MMP-9 protein play a vital role in suppression of the metastasis of non-small cell lung cancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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